Serveur d'exploration sur les relations entre la France et l'Australie

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

The hD52 (TPD52) gene is a candidate target gene for events resulting in increased 8q21 copy number in human breast carcinoma

Identifieur interne : 00BF28 ( Main/Exploration ); précédent : 00BF27; suivant : 00BF29

The hD52 (TPD52) gene is a candidate target gene for events resulting in increased 8q21 copy number in human breast carcinoma

Auteurs : Rosemary L. Balleine [Australie] ; Marlena Schoenberg Fejzo [États-Unis] ; Pavani Sathasivam [Australie] ; Paul Basset [France] ; Christine L. Clarke [Australie] ; Jennifer A. Byrne [Australie]

Source :

RBID : ISTEX:1DE600D56E84AA1AFEE51FC1FF0060EC9048A6FC

English descriptors

Abstract

Chromosome band 8q21 is frequently overrepresented in human cancer, but to date no 8q21 target gene has been proposed. The hD52 (TPD52) gene is of potential significance in breast and other cancers due to its location and expression pattern. Fine mapping of hD52 placed this locus within the peak of the 8q21 amplicon delineated in the SK‐BR‐3 breast carcinoma cell line, and a positive association between hD52 gene dosage and transcript levels was subsequently demonstrated in four breast carcinoma cell lines, including SK‐BR‐3. Increased copy number (ICN) was measured using Southern blot analyses in 3/32 human breast carcinomas at hD52, and the related hD54 gene in 20q13.2–q13.3. Subsequent immunohistochemical analysis of hD52 expression in 19 breast carcinomas with varying hD52 gene dosages demonstrated a significant positive association between hD52 dosage and hD52 expression using a Spearman rank correlation coefficient (rs = 0.573, α = 0.01) and a Wilcoxon rank‐sum test (α = 0.05). On the basis of its map location and expression pattern in breast carcinoma, we therefore propose hD52 as a candidate target gene at chromosome band 8q21. Genes, Chromosomes and Cancer 29:48–57, 2000. © 2000 Wiley‐Liss, Inc.

Url:
DOI: 10.1002/1098-2264(2000)9999:9999<::AID-GCC1005>3.0.CO;2-O


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

<record>
<TEI wicri:istexFullTextTei="biblStruct">
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">The hD52 (TPD52) gene is a candidate target gene for events resulting in increased 8q21 copy number in human breast carcinoma</title>
<author>
<name sortKey="Balleine, Rosemary L" sort="Balleine, Rosemary L" uniqKey="Balleine R" first="Rosemary L." last="Balleine">Rosemary L. Balleine</name>
</author>
<author>
<name sortKey="Fejzo, Marlena Schoenberg" sort="Fejzo, Marlena Schoenberg" uniqKey="Fejzo M" first="Marlena Schoenberg" last="Fejzo">Marlena Schoenberg Fejzo</name>
</author>
<author>
<name sortKey="Sathasivam, Pavani" sort="Sathasivam, Pavani" uniqKey="Sathasivam P" first="Pavani" last="Sathasivam">Pavani Sathasivam</name>
</author>
<author>
<name sortKey="Basset, Paul" sort="Basset, Paul" uniqKey="Basset P" first="Paul" last="Basset">Paul Basset</name>
</author>
<author>
<name sortKey="Clarke, Christine L" sort="Clarke, Christine L" uniqKey="Clarke C" first="Christine L." last="Clarke">Christine L. Clarke</name>
</author>
<author>
<name sortKey="Byrne, Jennifer A" sort="Byrne, Jennifer A" uniqKey="Byrne J" first="Jennifer A." last="Byrne">Jennifer A. Byrne</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:1DE600D56E84AA1AFEE51FC1FF0060EC9048A6FC</idno>
<date when="2000" year="2000">2000</date>
<idno type="doi">10.1002/1098-2264(2000)9999:9999<::AID-GCC1005>3.0.CO;2-O</idno>
<idno type="url">https://api.istex.fr/document/1DE600D56E84AA1AFEE51FC1FF0060EC9048A6FC/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000560</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000560</idno>
<idno type="wicri:Area/Istex/Curation">000560</idno>
<idno type="wicri:Area/Istex/Checkpoint">001F62</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001F62</idno>
<idno type="wicri:doubleKey">1045-2257:2000:Balleine R:the:hd:tpd</idno>
<idno type="wicri:Area/Main/Merge">00CE41</idno>
<idno type="wicri:Area/Main/Curation">00BF28</idno>
<idno type="wicri:Area/Main/Exploration">00BF28</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title level="a" type="main" xml:lang="en">The
<hi rend="italic">hD52</hi>
(
<hi rend="italic">TPD52</hi>
) gene is a candidate target gene for events resulting in increased 8q21 copy number in human breast carcinoma</title>
<author>
<name sortKey="Balleine, Rosemary L" sort="Balleine, Rosemary L" uniqKey="Balleine R" first="Rosemary L." last="Balleine">Rosemary L. Balleine</name>
<affiliation wicri:level="4">
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Westmead Institute for Cancer Research, University of Sydney, Westmead Hospital, Westmead, N.S.W.</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Fejzo, Marlena Schoenberg" sort="Fejzo, Marlena Schoenberg" uniqKey="Fejzo M" first="Marlena Schoenberg" last="Fejzo">Marlena Schoenberg Fejzo</name>
<affiliation wicri:level="2">
<country>États-Unis</country>
<placeName>
<region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Human Genetics, University of California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Sathasivam, Pavani" sort="Sathasivam, Pavani" uniqKey="Sathasivam P" first="Pavani" last="Sathasivam">Pavani Sathasivam</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Oncology Research Unit, The New Children's Hospital, Parramatta, N.S.W.</wicri:regionArea>
<wicri:noRegion>N.S.W.</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Basset, Paul" sort="Basset, Paul" uniqKey="Basset P" first="Paul" last="Basset">Paul Basset</name>
<affiliation wicri:level="1">
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Génétique et de Biologie Moléculaire et Cellulaire CNRS/INSERM/ULP, Illkirch Cedex</wicri:regionArea>
<wicri:noRegion>Illkirch Cedex</wicri:noRegion>
<wicri:noRegion>Illkirch Cedex</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Clarke, Christine L" sort="Clarke, Christine L" uniqKey="Clarke C" first="Christine L." last="Clarke">Christine L. Clarke</name>
<affiliation wicri:level="4">
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Westmead Institute for Cancer Research, University of Sydney, Westmead Hospital, Westmead, N.S.W.</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Byrne, Jennifer A" sort="Byrne, Jennifer A" uniqKey="Byrne J" first="Jennifer A." last="Byrne">Jennifer A. Byrne</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Oncology Research Unit, The New Children's Hospital, Parramatta, N.S.W.</wicri:regionArea>
<wicri:noRegion>N.S.W.</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4">
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Paediatrics and Child Health, University of Sydney, The New Children's Hospital, Parramatta, N.S.W.</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<country wicri:rule="url">Australie</country>
</affiliation>
<affiliation wicri:level="1">
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Correspondence address: Oncology Research Unit, The New Children's Hospital, P.O. Box 3515, Parramatta 2124, N.S.W.</wicri:regionArea>
<wicri:noRegion>N.S.W.</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series>
<title level="j" type="main">Genes, Chromosomes and Cancer</title>
<title level="j" type="alt">GENES, CHROMOSOMES AND CANCER</title>
<idno type="ISSN">1045-2257</idno>
<idno type="eISSN">1098-2264</idno>
<imprint>
<biblScope unit="vol">29</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="48">48</biblScope>
<biblScope unit="page" to="57">57</biblScope>
<biblScope unit="page-count">10</biblScope>
<publisher>John Wiley & Sons, Inc.</publisher>
<pubPlace>New York</pubPlace>
<date type="published" when="2000-09">2000-09</date>
</imprint>
<idno type="ISSN">1045-2257</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt>
<idno type="ISSN">1045-2257</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Amplicon peak</term>
<term>Antiserum</term>
<term>Biol chem</term>
<term>Breast</term>
<term>Breast cancer</term>
<term>Breast cancer amplicon</term>
<term>Breast cancer cell lines</term>
<term>Breast cancers</term>
<term>Breast carcinoma</term>
<term>Breast carcinoma cell line</term>
<term>Breast carcinoma cell lines</term>
<term>Breast carcinoma sections</term>
<term>Breast carcinoma specimens</term>
<term>Breast carcinoma tissues</term>
<term>Breast carcinomas</term>
<term>Breast epithelial tissue</term>
<term>Breast tumors</term>
<term>Broblastic cells</term>
<term>Byrne</term>
<term>Cancer cells</term>
<term>Candidate target gene</term>
<term>Carcinoma</term>
<term>Cdna probes</term>
<term>Cell lines</term>
<term>Cellular oncogenes</term>
<term>Chemiluminescent detection</term>
<term>Chromosomal</term>
<term>Chromosomal gains</term>
<term>Chromosomal imbalances</term>
<term>Chromosome</term>
<term>Chromosome band</term>
<term>Chromosome bands</term>
<term>Clinical outcome</term>
<term>Cocultured mcf7 breast carcinoma</term>
<term>Cold buffer</term>
<term>Comparative genomic hybridization</term>
<term>Control incubations</term>
<term>Copy number</term>
<term>Copy number increases</term>
<term>Courjal</term>
<term>Cytoplasmic staining</term>
<term>Dosage</term>
<term>Ductal carcinomas</term>
<term>Expression pattern</term>
<term>Fejzo</term>
<term>Fine mapping</term>
<term>Gene</term>
<term>Gene dosage</term>
<term>Genes chromosomes cancer</term>
<term>Genetic alterations</term>
<term>Genetic changes</term>
<term>Genomic</term>
<term>Growth advantage</term>
<term>Hepatocellular carcinoma</term>
<term>Hfl1 cells</term>
<term>Human breast cancer</term>
<term>Human breast cancer cell line</term>
<term>Human breast carcinoma</term>
<term>Human breast carcinoma cell lines</term>
<term>Human breast carcinoma sections</term>
<term>Human breast carcinomas</term>
<term>Human cancer</term>
<term>Hybridization</term>
<term>Hybridization signals</term>
<term>Immunohistochemical analysis</term>
<term>Invasive</term>
<term>Invasive cancer cells</term>
<term>Invasive ductal carcinoma</term>
<term>Isola</term>
<term>Jackson immunoresearch</term>
<term>Kallioniemi</term>
<term>Lane loading</term>
<term>Leukemic cells</term>
<term>Locus</term>
<term>Locus maps</term>
<term>Lung cancer</term>
<term>Mcf7</term>
<term>Mcf7 cells</term>
<term>Middle panel</term>
<term>Moderate levels</term>
<term>Multiple cancers</term>
<term>Northern blot analyses</term>
<term>Northern blot analysis</term>
<term>Oncogene</term>
<term>Oncology research unit</term>
<term>Other cancers</term>
<term>Other types</term>
<term>Ovarian cancer</term>
<term>Overexpression</term>
<term>Peptide</term>
<term>Polyclonal antisera</term>
<term>Positive association</term>
<term>Positive control</term>
<term>Positive relationship</term>
<term>Present study</term>
<term>Previous study</term>
<term>Primary antibody</term>
<term>Primary breast cancers</term>
<term>Primary breast carcinomas</term>
<term>Proc natl acad</term>
<term>Prostate cancer</term>
<term>Protease inhibitors</term>
<term>Protein extracts</term>
<term>Relative copy number</term>
<term>Schoenberg</term>
<term>Schoenberg fejzo</term>
<term>Signal intensities</term>
<term>Sodium phosphate buffer</term>
<term>Soluble extracts</term>
<term>Southern blot analyses</term>
<term>Spearman rank correlation</term>
<term>Standard procedures</term>
<term>Target gene</term>
<term>Tissue pathology</term>
<term>Transcript</term>
<term>Transcript levels</term>
<term>Western blot analyses</term>
<term>Westmead hospital</term>
<term>Wilcoxon test</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en">
<term>Amplicon peak</term>
<term>Antiserum</term>
<term>Biol chem</term>
<term>Breast</term>
<term>Breast cancer</term>
<term>Breast cancer amplicon</term>
<term>Breast cancer cell lines</term>
<term>Breast cancers</term>
<term>Breast carcinoma</term>
<term>Breast carcinoma cell line</term>
<term>Breast carcinoma cell lines</term>
<term>Breast carcinoma sections</term>
<term>Breast carcinoma specimens</term>
<term>Breast carcinoma tissues</term>
<term>Breast carcinomas</term>
<term>Breast epithelial tissue</term>
<term>Breast tumors</term>
<term>Broblastic cells</term>
<term>Byrne</term>
<term>Cancer cells</term>
<term>Candidate target gene</term>
<term>Carcinoma</term>
<term>Cdna probes</term>
<term>Cell lines</term>
<term>Cellular oncogenes</term>
<term>Chemiluminescent detection</term>
<term>Chromosomal</term>
<term>Chromosomal gains</term>
<term>Chromosomal imbalances</term>
<term>Chromosome</term>
<term>Chromosome band</term>
<term>Chromosome bands</term>
<term>Clinical outcome</term>
<term>Cocultured mcf7 breast carcinoma</term>
<term>Cold buffer</term>
<term>Comparative genomic hybridization</term>
<term>Control incubations</term>
<term>Copy number</term>
<term>Copy number increases</term>
<term>Courjal</term>
<term>Cytoplasmic staining</term>
<term>Dosage</term>
<term>Ductal carcinomas</term>
<term>Expression pattern</term>
<term>Fejzo</term>
<term>Fine mapping</term>
<term>Gene</term>
<term>Gene dosage</term>
<term>Genes chromosomes cancer</term>
<term>Genetic alterations</term>
<term>Genetic changes</term>
<term>Genomic</term>
<term>Growth advantage</term>
<term>Hepatocellular carcinoma</term>
<term>Hfl1 cells</term>
<term>Human breast cancer</term>
<term>Human breast cancer cell line</term>
<term>Human breast carcinoma</term>
<term>Human breast carcinoma cell lines</term>
<term>Human breast carcinoma sections</term>
<term>Human breast carcinomas</term>
<term>Human cancer</term>
<term>Hybridization</term>
<term>Hybridization signals</term>
<term>Immunohistochemical analysis</term>
<term>Invasive</term>
<term>Invasive cancer cells</term>
<term>Invasive ductal carcinoma</term>
<term>Isola</term>
<term>Jackson immunoresearch</term>
<term>Kallioniemi</term>
<term>Lane loading</term>
<term>Leukemic cells</term>
<term>Locus</term>
<term>Locus maps</term>
<term>Lung cancer</term>
<term>Mcf7</term>
<term>Mcf7 cells</term>
<term>Middle panel</term>
<term>Moderate levels</term>
<term>Multiple cancers</term>
<term>Northern blot analyses</term>
<term>Northern blot analysis</term>
<term>Oncogene</term>
<term>Oncology research unit</term>
<term>Other cancers</term>
<term>Other types</term>
<term>Ovarian cancer</term>
<term>Overexpression</term>
<term>Peptide</term>
<term>Polyclonal antisera</term>
<term>Positive association</term>
<term>Positive control</term>
<term>Positive relationship</term>
<term>Present study</term>
<term>Previous study</term>
<term>Primary antibody</term>
<term>Primary breast cancers</term>
<term>Primary breast carcinomas</term>
<term>Proc natl acad</term>
<term>Prostate cancer</term>
<term>Protease inhibitors</term>
<term>Protein extracts</term>
<term>Relative copy number</term>
<term>Schoenberg</term>
<term>Schoenberg fejzo</term>
<term>Signal intensities</term>
<term>Sodium phosphate buffer</term>
<term>Soluble extracts</term>
<term>Southern blot analyses</term>
<term>Spearman rank correlation</term>
<term>Standard procedures</term>
<term>Target gene</term>
<term>Tissue pathology</term>
<term>Transcript</term>
<term>Transcript levels</term>
<term>Western blot analyses</term>
<term>Westmead hospital</term>
<term>Wilcoxon test</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Chromosome band 8q21 is frequently overrepresented in human cancer, but to date no 8q21 target gene has been proposed. The hD52 (TPD52) gene is of potential significance in breast and other cancers due to its location and expression pattern. Fine mapping of hD52 placed this locus within the peak of the 8q21 amplicon delineated in the SK‐BR‐3 breast carcinoma cell line, and a positive association between hD52 gene dosage and transcript levels was subsequently demonstrated in four breast carcinoma cell lines, including SK‐BR‐3. Increased copy number (ICN) was measured using Southern blot analyses in 3/32 human breast carcinomas at hD52, and the related hD54 gene in 20q13.2–q13.3. Subsequent immunohistochemical analysis of hD52 expression in 19 breast carcinomas with varying hD52 gene dosages demonstrated a significant positive association between hD52 dosage and hD52 expression using a Spearman rank correlation coefficient (rs = 0.573, α = 0.01) and a Wilcoxon rank‐sum test (α = 0.05). On the basis of its map location and expression pattern in breast carcinoma, we therefore propose hD52 as a candidate target gene at chromosome band 8q21. Genes, Chromosomes and Cancer 29:48–57, 2000. © 2000 Wiley‐Liss, Inc.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Australie</li>
<li>France</li>
<li>États-Unis</li>
</country>
<region>
<li>Californie</li>
<li>Nouvelle-Galles du Sud</li>
</region>
<settlement>
<li>Sydney</li>
</settlement>
<orgName>
<li>Université de Sydney</li>
</orgName>
</list>
<tree>
<country name="Australie">
<region name="Nouvelle-Galles du Sud">
<name sortKey="Balleine, Rosemary L" sort="Balleine, Rosemary L" uniqKey="Balleine R" first="Rosemary L." last="Balleine">Rosemary L. Balleine</name>
</region>
<name sortKey="Byrne, Jennifer A" sort="Byrne, Jennifer A" uniqKey="Byrne J" first="Jennifer A." last="Byrne">Jennifer A. Byrne</name>
<name sortKey="Byrne, Jennifer A" sort="Byrne, Jennifer A" uniqKey="Byrne J" first="Jennifer A." last="Byrne">Jennifer A. Byrne</name>
<name sortKey="Byrne, Jennifer A" sort="Byrne, Jennifer A" uniqKey="Byrne J" first="Jennifer A." last="Byrne">Jennifer A. Byrne</name>
<name sortKey="Byrne, Jennifer A" sort="Byrne, Jennifer A" uniqKey="Byrne J" first="Jennifer A." last="Byrne">Jennifer A. Byrne</name>
<name sortKey="Clarke, Christine L" sort="Clarke, Christine L" uniqKey="Clarke C" first="Christine L." last="Clarke">Christine L. Clarke</name>
<name sortKey="Sathasivam, Pavani" sort="Sathasivam, Pavani" uniqKey="Sathasivam P" first="Pavani" last="Sathasivam">Pavani Sathasivam</name>
</country>
<country name="États-Unis">
<region name="Californie">
<name sortKey="Fejzo, Marlena Schoenberg" sort="Fejzo, Marlena Schoenberg" uniqKey="Fejzo M" first="Marlena Schoenberg" last="Fejzo">Marlena Schoenberg Fejzo</name>
</region>
</country>
<country name="France">
<noRegion>
<name sortKey="Basset, Paul" sort="Basset, Paul" uniqKey="Basset P" first="Paul" last="Basset">Paul Basset</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00BF28 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 00BF28 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:1DE600D56E84AA1AFEE51FC1FF0060EC9048A6FC
   |texte=   The hD52 (TPD52) gene is a candidate target gene for events resulting in increased 8q21 copy number in human breast carcinoma
}}

Wicri

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024